When TRPV1 is activated by the stimulation signal, its central hole conformation changes, causing Ca2+ influx, resulting in increased intracellular Ca2+ concentration, and integrating the upstream stimulation signal into intracellular Ca2+ signal, mediating the downstream nerve and immune response through neurogenic inflammation and immunogenic inflammation, inducing a series of asthma symptoms [37]. Here, TRPV1 is linked to asthma.