And PTGS2 [32, 33], EGFR [34], ESR1 [35, 36], APP [37], IGF1R [38, 39], KDR [40], GSK3B [41, 42], MAPT [43], and PIK3R1 [44] played very important roles in prevalence and progression of depression. The gene discussed is ESR1; the disease is major depressive disorder.