The nutritional polyphenols found in BRBs have been shown to have pleiotropic effects against CRC initiation and progression.[5, 6, 7, 12] While there is strong evidence that BRBs reduce FAP polyp[7] and tumor burdens,[5, 6] alter the tumor microenvironment,[13, 14] and reduces cancer‐related inflammation,[5] there are limited studies on their effect on normal and malignant ISC populations. Here, FAP is linked to colorectal carcinoma.