TMPRSS2 and neoplasm: Previously attributed to an interstitial deletion or an insertional chromosomal rearrangements [38], of the 33 tumours identified as TMPRSS2-ERG fusion-positive in this study, 16 are the result of a single deletion event, two present with a deletion and each additionally with two matching translocations (2 pairs of BNDs), indicating retention of the interstitial region (Additional file 1: Fig. S5), and 10 present with a deletion with additional overlapping SVs.