ERG, PTEN, CSMD3 and LRP1B were previously identified as driver genes associated with PCa using this sample data source and PCAWG cohorts [6], while our new method highlighted 18 additional potential driver genes, including GABRB1, CLVS1, RNLS, TMPRSS2, TTC28, EYS, TTC6, PTPRD, PRKN, PACRG, TBC1D32, CADM2, LSAMP, MARCHF1, PDE4D, KCND2, EPHA6 and TEC. Among the gene candidates, EYS, PTPRD, PRKN, CSMD3, CADM2, LSAMP and PDE4D are larger than the defined genomic bin (1 Mbp) and as such we cannot exclude for their co-location with the SVs being a chance event. The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.