BRCA2 and neoplasm: While the two remaining hyper-deleted tumours, BRA08 (European) and KAL0013 (African), showed no BRCA2 loss, two or more nonsynonymous germline BRCA2 mutations were observed for each patient (Additional file 1: Table S3), although defined by ClinVar [December 2020] [32] as ‘benign’ or of ‘uncertain significance’.