Taking a closer look at TMPRSS2-ERG and their alternative partners, as well as all previously reported PCa relevant ETS family members, namely ETV1, ETV4 and ETV5 [10], we identified besides TMPRSS2-ERG, 20 TMPRSS2, 15 ERG, 2 ETV1 and 1 ETV4 partners, largely driven by translocations [35] and to a lesser extent by deletion [13], inversion [7] and duplication [2] events (Fig. 4A). The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.