Anaplastic Large Cell Lymphoma (ALCL), characterized by expression of CD30, refers to a family of Non-Hodgkin T cell lymphomas divided into four entities: systemic Anaplastic Lymphoma Kinase (ALK) positive (ALK+ ALCL), systemic ALK negative (ALK− ALCL), primary cutaneous ALCL (pc-ALCL) and breast-implant associated (BIA-ALCL) [1]. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.