ALK and non-small cell lung carcinoma: First-generation ALK tyrosine kinase inhibitor (TKI) crizotinib (Xalkori), initially approved by the Federal Drug Administration (FDA) for Non-Small Cell Lung Cancer (NSCLC) patients harboring ALK fusions, has recently been authorized for pediatric patients with relapsed or refractory systemic ALK+ ALCL (NCT00939770).