CRC is reported to be the most common cancer entity that harbors TP53 variation, with 43.28% of CRCs reported to have TP53 variation (IARC TP53 database, R20; https://p53.iarc.fr/TP53SomaticVariations.aspx, accessed on 27 October 2021). The gene discussed is TP53; the disease is colorectal carcinoma.