Although the accumulation of CD8+ T cells was confirmed by another scRNA-seq analysis of immune cell populations in checkpoint inhibitor-induced colitis (CPI), the percentage of FOXP3+ Treg cells was found to be significantly elevated in CPI patients (Luoma et al., 2020), and the increase of special FOXP3/BATF+ Treg cells and IL1B/LYZ+ myeloid cells were confirmed by another study in inflamed UC patients (Devlin et al., 2021). This evidence concerns the gene FOXP3 and isolated cleft palate.