Analysis of cancer stem cells in CRC in ApcMin/+ mouse adenoma at various time points during chemoradiotherapy suggests that tumor-initiating cells can shape the tumor environment into a landscape, which renders resistance to immunosuppression by forming an immune barrier against CD8+ T cells and promotes the proliferation of therapy-resistant cancer stem cells via Cox-2/PGE2 signaling (He et al., 2021).. The gene discussed is CD8A; the disease is cancer.