These syndromes, such as cachexia and sarcopenia, manifest upon long-term systemic inflammatory responses that accompany chronic diseases, including cancer, chronic kidney disease, thyroid disease, chronic liver failure, etc. In addition to maintaining energy homeostasis, healthy adipocytes secrete adipokines, such as leptin, that co-ordinate metabolism, muscle growth, and myocardial health70,71. Here, LEP is linked to chronic kidney disease.