In light of the previous finding that cardiac-specific overexpression of HK2 augments PPP flux and attenuates cardiac hypertrophy,49 and hexokinase activation is linked to increased PPP activity during acute kidney injury,50 it might be explained by the condition that HK2 lies upstream to glycolysis/PPP shunt and thus unbiasedly enhances glucose flux. Here, HK2 is linked to cardiac hypertrophy.