From the differential genes involved in these pathways, we identified several gene clusters uniquely upregulated in the CAFWPOI 4-5 type; neuronal development and function-related (RELN, MYH10, CACNB4, OXTR, CAV3, CHRM2) and inflammation and cancer-related (RELN, IL21R, EDNRB, CAV3, OXTR) (Fig. 3a). This evidence concerns the gene RELN and cancer.