Our previous studies show that ISO treatment induces miR-145 expression in both human BC cells and human glioblastoma cells [18, 38], Moreover, in human glioblastoma cells, ISO treatment inhibits SOX2 mRNA 3’UTR activity; and the point mutation of miR-145 binding site in SOX2 mRNA 3’UTR also reveals that miR-145 inhibits SOX2 protein translation by binding directly to the SOX2-3’UTR region [38]. Here, SOX2 is linked to glioblastoma.