O‐GlcNAcylation is a dynamic, ubiquitous, and metabolism‐sensitive process that depends on two key enzymes (OGT and OGA) and the substrate UDP‐GlcNAc.[70] Although the role of O‐GlcNAcylation in regulating protein homeostasis,[48, 49] localization,[71, 72] and transcriptional activity[73, 74] has been widely appreciated, its role in the functional and mechanistic modulation of tumor angiogenesis remain unclear, especially under stress conditions, such as hypoxia and nutrient scarcity. This evidence concerns the gene OGA and neoplasm.