elucidated that increasing levels of O‐GlcNAcylation in prostate cancer cells caused increased invasion and angiogenesis by inducing the expression of matrix metalloproteinase (MMP)‐2, MMP‐9, and VEGF.[79] However, in the present study, we demonstrate, for the first time, that the increasing HBP flux‐mediated increase in O‐GlcNAc modifications in ECs facilitates tumor angiogenesis. Here, MMP2 is linked to prostate carcinoma.