To further elucidate the secretory mechanism of sEVs‐GFAT1, we first established GFKO and OEGF stable cell lines and found that the variations in GFAT1 levels in BCa cells and sEVs were synergistic, implying that the expression of GFAT1 in tumor cells directly influences the sEVs‐GFAT1 level in the TME (Figure S3A–D, Supporting Information). The gene discussed is GFPT1; the disease is neoplasm.