Collectively, the present results provide a new perspective on the effect of BCa‐derived sEVs‐GFAT1 on metabolic reprogramming in the TME and expand our understanding of HBP‐induced SerRS O‐GlcNAcylation in ECs on promoting tumor angiogenesis, which may shed light on novel targets for BCa antiangiogenetic therapy. This evidence concerns the gene GFPT1 and neoplasm.