elucidated that increasing levels of O‐GlcNAcylation in prostate cancer cells caused increased invasion and angiogenesis by inducing the expression of matrix metalloproteinase (MMP)‐2, MMP‐9, and VEGF.[79] However, in the present study, we demonstrate, for the first time, that the increasing HBP flux‐mediated increase in O‐GlcNAc modifications in ECs facilitates tumor angiogenesis. This evidence concerns the gene MMP2 and Familial prostate cancer.