For example, five‐fluorouracil‐resistant colon cancer cell‐derived sEVs containing dipeptidyl peptidase IV (DPP4) increased periostin expression levels in ECs and promoted angiogenesis by facilitating Twist1 nuclear translocation and inducing Smad pathway activation.[66] Lysyl oxidase‐like 4 (LOXL4) is transferred to ECs by hepatocellular carcinoma cell‐derived sEVs, leading to angiogenesis by activating the FAK/Src signaling pathway.[67] However, little is known about the roles of key metabolic enzymes delivered by tumor‐derived sEVs in the functional and mechanistic regulation of ECs. The gene discussed is TWIST1; the disease is colonic neoplasm.