This MLH1 variant, which has been classified as NOT pathogenic on the basis of criteria developed by the InSiGHT Mutation Interpretation Committee, has previously been reported in the literature in association with MLH1 IHC loss.21 IHC at our institution using a different antibody clone (Cell Marque G168-728) revealed intact expression of MLH1 (Fig 1), and the neoplasm was subsequently reclassified as MMR-proficient. This evidence concerns the gene MRC1 and neoplasm.