A non-significant trend towards an increase in serum PAI-1 levels was observed comparing T2D (549.9±134.8 ng/ml), obese non-diabetic control subjects (508.2±164.9 ng/ml) and lean control subjects 383.75±104.54 ng/ml (P = 0.053) (Fig 1B). Here, SERPINE1 is linked to type 2 diabetes mellitus.