Since the asymmetric synaptic connections between sprouted mossy fibers and dendritic spines constitute the structural basis for neural hyper synchronization and spontaneous recurrent seizures, disease-modifying therapies targeting signaling pathways regulating neural rewiring such as Sema3F/Npn-2 signaling are promising in treating epilepsy in adulthood. The gene discussed is NRP2; the disease is epilepsy.