FIS1 and Parkinson disease: Importantly, this pathway is selectively inhibited by disrupting Fis1 oligomerization: both mutant Fis1, which disrupts Fis1 oligomerization, and oligomerization domain Mid51(R169W) mutant potentially linked to Parkinson’s disease, which also disrupts Fis1 oligomerization, result in inefficient inter-lysosomal untethering events.