Of the four proteins (PlGF, BDNF, Mip-1β and TNF-β) that indicated a univariate association with group (higher in participants without cognitive impairment) but not continuous performance, only PlGF contributed significantly (P < 0.05) to both cognitive outcomes in multivariable regression models (also containing medications, health-related quality of life, gender, smoking, age and FAST). Here, PGF is linked to Cognitive impairment.