PGF and bipolar disorder: PlGF is a ligand of VEGFR and is involved in the recruitment of monocytes and macrophages, which promote vessel growth and angiogenesis.25 Similar to VEGF-C above, we identified a significant and positive association between PlGF and overall cognitive performance, although this was not apparent when assessing individual cognitive domains, and we are not aware of previous studies of PlGF in people with bipolar disorder.