Moreover, IGFBP7 was a prognostic biomarker of glioma and IGFBP7 was correlated with the overall survival of glioma in TCGA‐GBMLGG, CCGA‐GBMLGG, GSE4412‐GBMLGG and GSE43378‐GBMLGG four independent glioma cohorts (Figure 6C). This evidence concerns the gene IGFBP7 and central nervous system cancer.