Glioma patients with IGFBP7 lower expressions had prolonged overall survival compared with glioma patients with IGFBP7 higher expressions in TCGA‐GBMLGG, CCGA‐GBMLGG, GSE4412 ‐GBMLGG and GSE43378 ‐GBMLGG datasets (Figure 6D). This evidence concerns the gene IGFBP7 and central nervous system cancer.