The phosphorylated HGFR and MST1R could activate several transduction proteins and trigger their downstream signalling cascades which mainly included phosphatidylin-ositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway, mitogen-activated protein kinase (MAPK) pathway, signal transducer and activator of transcription (STAT) pathway, cell sarcoma (c-Src), and extracellular regulated protein kinase1/2 (ERK1/2), etc.13–17. This evidence concerns the gene AKT1 and sarcoma.