Our previous studies demonstrated that both vascular endothelial growth factor and antimicrobial peptides (β‐defensin and cathelicidin‐related antimicrobial peptides) are required for epidermal permeability barrier homeostasis,23, 24 whereas high glucose (a symptom of diabetes) decreases expression levels of vascular endothelial growth factor, β‐defensin, and cathelicidin in keratinocytes in vivo and in vitro.25 This evidence concerns the gene VEGFA and diabetes mellitus.