As shown in Figure 4e and f, MDM2 was highly expressed in both the tissues and tissue associated EVs analysed when compared to NAT and NAT EV (mean: NAT = 0.076 ± sd 0.0009, RL tumour = 2.809 ± sd 1.240, p = 0.0029; NAT EVs 0.13 ± sd 0.11, RL tumour EVs = 1.9 ± sd 0.98; p = 0.002). This evidence concerns the gene MDM2 and neoplasm.