ApoB, a 550 kDa protein previously implicated as a risk and prognostic factor associated with ALS,25–27 was significantly upregulated in sALS CSF versus HC CSF, downregulated in 5 kDa-filtered sALS CSF and the sole candidate which met the molecular weight criteria (Fig. 8A and B). The gene discussed is APOB; the disease is amyotrophic lateral sclerosis.