Myelin oligodendrocyte glycoprotein (MOG), haptoglobin, apolipoprotein C-III (ApoC-III), and apolipoprotein E (ApoE), all failed to recapitulate the motor disability and motor neuron degeneration observed with sALS CSF and ApoB (Fig. 9A-D). This evidence concerns the gene APOE and Motor neuron atrophy.