As IGFBP5 is known to directly antagonise IGF-1 signalling,29, 30, 31 with evidence that exogenous growth hormone treatment can cause carpal tunnel syndrome,29 we hypothesised that higher IGF-1 plasma levels would be associated with significantly increased risk of both trigger finger and carpal tunnel syndrome in UK Biobank participants. This evidence concerns the gene GH1 and carpal tunnel syndrome.