Our single-cell eQTL analysis provided evidence to show that this variant was associated with tissue-specific modulation of the expression of DIRC3 and its known downstream effector, IGFBP5. Bulk RNA sequencing analysis of surgically resected tenosynovium samples from patients with carpal tunnel syndrome showed that this protective variant was associated with enhanced expression of IGFBP5. Considering that IGFBP5 is an antagonist of IGF-1, we found that both trigger finger and carpal tunnel syndrome were positively associated with IGF-1 levels. Here, IGF1 is linked to carpal tunnel syndrome.