As IGFBP5 is known to directly antagonise IGF-1 signalling,29, 30, 31 with evidence that exogenous growth hormone treatment can cause carpal tunnel syndrome,29 we hypothesised that higher IGF-1 plasma levels would be associated with significantly increased risk of both trigger finger and carpal tunnel syndrome in UK Biobank participants. The gene discussed is IGFBP5; the disease is carpal tunnel syndrome.