MOK1, MAPK/MAK/MRK overlapping kinase1;<br>mTOR, Mammalian target of rapamycin;<br>mTORC1, Mammalian target of rapamycin complex 1;<br>NLRP3, NLR family pyrin domain containing 3;<br>PBMC, Peripheral blood mono -nuclear cell;<br>T1DM, Type 1 diabetes mellitus;<br>T2DM, Type 2 diabetes mellitus. The gene discussed is MAK; the disease is type 1 diabetes mellitus.