Czarkowsk et al. found that long-term stimulation with large amounts of thyroid hormone can also reduce the toughness of blood vessels, leading to the hardening of the arteries.[19] Simultaneously, thyroid hormones can promote oxidative phosphorylation, increase heat production and oxygen consumption, and cause profuse sweating, leading to a decrease in the body’s effective circulating blood volume and hemoconcentration, which ultimately lead to the occurrence of cerebrovascular diseases. This evidence concerns the gene TG and cerebrovascular disorder.