4H leukodystrophy was first mentioned and reported 4 cases of patients with dysmyelination of brain white matter, hypogonadotropic hypogonadism, and tooth deformity in 2006.[1] Bernard et al[2] reported that 4H leukodystrophy was caused by POLR3A nucleotide variation in 2011. The gene discussed is POLR3A; the disease is hypogonadotropic hypogonadism.