PITX2 and Familial prostate cancer: Although the single nucleotide polymorphism (SNP) of AXIN2 rs2240308 at codon 50 is not located in the APC binding site, the site of codon 50 is quite close to the RGS domain, which may affect the affinity between AXIN2 and APC, leading to abnormal regulation of β-Catenin and permit carcinogenesis,[28] which have been reported in lung and prostate cancer.