A combination of the 2 interventions is better than an individual intervention.[27] A systematic review showed that 8 weeks of high-intensity exercise could reduce C-reactive protein.[28] However, an exercise intervention study for patients with chronic kidney disease showed that albumin and C-reactive protein did not change before and after exercise intervention.[28] Muscle contraction caused by resistance training leads to the production of muscle cytokines. Here, CRP is linked to chronic kidney disease.