In the previous study, up-regulated MIF concentration led to produce IL6 and IL8 from macrophage, and the increment of IL6 and IL8 could aggravate the inflammatory process in NEC.[18] However, Prencipe et al[19] reported functionally relevant polymorphism of -173G/C of MIF promoter, which were associated with higher MIF expression, did not play a role in the development of NEC. The gene discussed is CXCL8; the disease is necrotizing enterocolitis.