OXTR and obesity due to melanocortin 4 receptor deficiency: Along those lines, a recent study on childhood obesity impressively illustrates the influence of gene × environment (G × E) interactions within the OXTR [18]: Carriers of the A allele of the OXTR rs53576 variant were especially affected by obesity when they grew up in lower socioeconomic background families, but were less affected when their families were characterized by a higher socioeconomic status.