Using all available clinical information (n = 342), we found that IDH2 tumours tended to be larger at time of presentation (IDH1 vs IDH2: p = 0.001, IDH1 vs IDHwt: p = 0.4, Fig. 3A), supporting the premise that these tumours evolve over longer time periods, and present in older people. The gene discussed is IDH2; the disease is neoplasm.