IDH2 and neoplasm: The age at diagnosis for each IDH group was similar for ACT/G1 and DD CS, and the difference in age of the G2/3 tumours explained the overall difference in ages (median age G2/3, IDH1: 60 year, IDH2: 71 year, IDHwt: 44 year, IDH1vs IDH2: p = 0.04, IDH1 vs IDHwt: p = 2e−6, Fig. 2B).