No recurrent initiating genetic drivers have been reported in the remaining 30% of IDH1/2 wild type (IDHwt) cases [12, 13], although these tumours have been reported to exhibit different methylation profiles compared to IDH1 and IDH2-mutant tumours [14, 15], hereafter referred to as IDH1 and IDH2 tumours. Here, IDH2 is linked to neoplasm.