IDH2 and neoplasm: We showed that patient age at diagnosis increased across grades in these groups and that the median age was highest in those with IDH2 tumours (IDH1: 55 year, IDH2: 67 year, IDHwt: 47 year, IDH1 vs IDH2: p = 0.003, IDH1 vs IDHwt: p = 0.0006, Fig. 2A).