Canonical TERT promoter mutations (g.1295113) had an independent hazard ratio (HR) that was equal to that of grade (TERT: HR = 2.2, p = 0.003, tumour grade: HR = 2.2, p = 2e−13, Additional file 3: Supplementary Fig. 8), pointing to the benefit of TERT as a biomarker. The gene discussed is TERT; the disease is neoplasm.