HK2 and arthritic joint disease: Wang et al. used glycolysis inhibitor 2-deoxyglucose (2-DG) to treat adjuvant arthritis (AA) rats, and found that HK2 expression was positively correlated with synovial hyperplasia, inflammatory cell infiltration and cartilage destruction, which further confirmed that the effect of HK2 glycolysis inhibitor is closely related to the activation and inhibition of NF-κB signaling [98].