It is not known whether cerebral cortex lesions in MS may involve the expression of CCL2, as cortex lesions have been not characterized in studies that described CCL2 expression (17), and CCL2 expression associated to microglia activation has not been investigated in studies that evaluated the levels of pro-inflammatory cytokines in different brain areas, including the cerebral cortex, in experimental conditions of systemic neuroinflammation [81]. This evidence concerns the gene CCL2 and myeloid sarcoma.