Kaplan-Meier Plotter [26] showed that breast cancer patients with high S6K1 expression had significantly worse relapse-free survival (hazard ratio = 1.31, P < 0.0001), especially in the ER+ subgroup (hazard ratio = 1.34, P = 0.0013, Fig. 2E). The gene discussed is ESR1; the disease is breast carcinoma.