In addition, an animal experiment found that a recombinant plasmid formed by the H. pylori virulence genes CagA, VacA, and BabA could induce CD3+ T cells in animals and had antitumor activity in both in vivo and in vitro experiments [65], suggesting that H. pylori infection may be an important factor influencing the efficacy of gastric cancer immunotherapy. This evidence concerns the gene S100A8 and gastric cancer.