This is consistent with reports in other herpesviruses including HCMV, human herpes simplex virus 1 (HSV1), EBV and KSHV, where isolates display uneven distribution of diversity, with high diversity observed in genes required for persistence viral infection and latency establishment, including structural genes and some glycoproteins [64, 70, 86, 101]. This evidence concerns the gene ART4 and viral infectious disease.