We utilized hucMSC exosomes carrying miR-375-interfering PMO oligomer (e-375i) to silence miR-375 in PCa cells and found that systematic administration of e-375i could efficiently enter PCa cells, knock down miR-375, upregulate PTPN4, and downregulate p-STAT3, eventually blocking the growth of PCa in vivo and in vitro. This evidence concerns the gene PTPN4 and posterior cortical atrophy.