In parallel, PTPN4 overexpression in PCa cells reversed the miR-375-induced insensitivity (Fig. 9e, f) with downregulation of p-STAT3 (Fig. 4g), while PTPN4 depletion in PCa cells reversed the miR-375 inhibition-enhanced sensitivity (Fig. 9g, h), and e-375i also significantly reduced PCa cell enzalutamide resistance (Fig. 9i, j). Here, PTPN4 is linked to posterior cortical atrophy.