Several IFN risk allele variants are involved in the induction of prolonged IFN signaling in a variety of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, vasculitis and primary biliary cholangitis (PBC) [17–24]. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.