Several IFN risk allele variants are involved in the induction of prolonged IFN signaling in a variety of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, vasculitis and primary biliary cholangitis (PBC) [17–24]. The gene discussed is IFNA1; the disease is systemic sclerosis.