AICDA and B-cell chronic lymphocytic leukemia: Although research has been done to develop AID inhibitors and it has been suggested that an AID inhibitor can be used to treat B cell malignancies [43, 44], the exacerbation of CLL in AID−/−/Eμ-TCL1 mice suggests that these inhibitors could have the unintended effect of generating a more aggressive CLL.