To determine the molecular mechanisms behind the more malignant phenotypes of AID-deficient CLL cells in an unbiased manner, we performed RNA-sequencing on Eμ-TCL1 and AID−/−/Eμ-TCL1 CLL cells and analyzed the data by gene set enrichment analysis (GSEA). Here, AICDA is linked to B-cell chronic lymphocytic leukemia.