Besides, we explored alterations and mutations in GSDMC and its frequently altered neighbor genes in BRCA, then found that GSDMC alterations were considerably correlated with the cancer-associated genes in BRCA, including CASC8, POU5F1B, PVT1, TMEM75, MYC, CYRIB, RN7SKP226, CCDC26, CCAT1 and LINC00977. This evidence concerns the gene CASC8 and cancer.