In PAAD and KIRP, high GSDMC expressions were associated with poorer relapse-free survival (RFS) (PAAD, HR = 2.98 (1.21–7.35), P = 0.013; KIRP, HR 2.95 (1.4–6.2), P = 0.0027), but no significant associations with OS (PAAD, HR 1.5 (0.99–2.28), P = 0.054; KIRP, HR 1.6 (0.88–2.92), P = 0.12) (Fig. 6G–J). Here, GSDMC is linked to pancreatic adenocarcinoma.