SIGLEC15, PDCD1LG2 (PD-L2), TIGIT, PDCD1 (PD-1), CD274 (PD-L1), CTLA4, LAG3, and HAVCR2 (TIM3) are transcripts related to immunological checkpoints that perform a vital function in tumor immune evasion. The gene discussed is SIGLEC15; the disease is neoplasm.