Besides function on STAT1 activity, a recent report has demonstrated that in oesophageal cancer, the RNF168, located in the nuclear, has a high frequency of gene amplification, which is correlated with overall poor survival for oesophageal cancer patients.304 The knockdown of RNF168 dramatically inhibits the proliferation and invasion of oesophageal cancer cells. Here, STAT1 is linked to carcinoma of esophagus.