RNF180 and gastric neoplasm: Genome-wide methylation screening among 198 gastric tumors revealed that the promoter methylation of RNF180 is detected in 76% of cases but none of the normal controls, indicating the RNF180 transcript is commonly silenced in gastric cancer.70 They further demonstrated that the RNF180 is a novel potential tumor suppressor in gastric cancer by suppressing cell growth and inducing apoptosis.