Recent work denoted that RNF106 (UHRF1) is downregulated in circulating T follicular helper (Tfh) cells isolated from peripheral blood mononuclear cells of SLE patients.117 They further showed that the RNF106 inhibits the expression of B cell lymphoma 6 (BCL6) by decreasing DNA methylation and H3K27me3 levels, thus enhancing Tfh cell differentiation, which cell group may be involved in the dysregulated antibody responses associated with SLE. The gene discussed is BCL6; the disease is systemic lupus erythematosus.