When combined with two zinc atoms, the RING domain forms a RING finger structure similar to the zinc finger, which can form a relatively stable binding region to provide a structural basis for the combination of E2 and to mediate the ubiquitination process effectively.15 Emerging evidence has shown that the RNF proteins are involved in many biological processes, and the abnormal function of RNF proteins, caused by genetic alterations, frequently contributes to several diseases, classified as cancer, immunological disease, and neuropsychiatric disorders. The gene discussed is TRIM31; the disease is cancer.