RNF115 (BCA2) has been shown to directly associate with the cytosolic domain of tetherin to accelerate the internalization of viral particles captured by tetherin on the plasma membrane, leading to the lysosomal degradation of HIV-1 virions in an RNF115’s catalysis‐independent manner.308 Their data might provide therapeutic clues on RNF115 for controlling AIDS and related disorders. This evidence concerns the gene BST2 and AIDS.