Previous studies have indicated that Kaposi’s sarcoma-associated herpesvirus (KSHV) could hijack RNF55 to promote viral internalization during infection of endothelial cells.212 However, whether the KSHV or other viruses hijack the RNF55-mediated inhibition of RIG-I to antagonize its antiviral function needs to be further addressed. This evidence concerns the gene RIGI and infection.