PRKN and colorectal carcinoma: An array of comparative genomic hybridization showed the Parkin deletion in 33% (33/100) CRCs, and the Parkin expression levels are dramatically lower in the CRC samples with deleted Parkin than in wild-type Parkin.85 In human CRC, the heterozygotic Parkin deletion is significantly associated with adenomatous polyposis coli (APC) deficiency, which plays an important role in regulating WNT signaling.