PRKN and Parkinson disease: AUTEN-99 (2-(4-Phenylphenyl)-5,6-Dihydroimidazo[2,1-B][1,3]Thiazole) activates the autophagy to alleviate neurodegenerative symptoms in the Drosophila model of PD and also HD, represented by overexpression human mutant Parkin (R275W) and HTT protein in Drosophila strain, respectively.171 The AUTEN-99 may be a potent drug candidate for preventing and treating PD caused by certain Parkin mutations.