RNF168 and carcinoma of esophagus: Besides function on STAT1 activity, a recent report has demonstrated that in oesophageal cancer, the RNF168, located in the nuclear, has a high frequency of gene amplification, which is correlated with overall poor survival for oesophageal cancer patients.304 The knockdown of RNF168 dramatically inhibits the proliferation and invasion of oesophageal cancer cells.