The RNF84 (TRAF5) stabilizes the RAR-related orphan receptor-γt (RORγt) via catalyzing K63-linked ubiquitination, thus facilitating the proinflammatory Th17 cell differentiation and IL17A/IL17F expression to aggravate inflammatory responses.116 Consistent with this observation, elevated expression of RNF84 is positively correlated with IL-17A in CD4+ T-cells from SLE patients, implicating that the RNF84 may contribute to SLE pathogenesis by ubiquitinating RORγt under inflammatory conditions. This evidence concerns the gene IL17F and systemic lupus erythematosus.