Besides, viral infection is a leading cause of infection-related cancers, accounting for over 15% of all cancers.16–18 It is also proposed to induce or exacerbate autoimmune responses or protect from certain immune disorders17,19 and contribute to the pathogenesis of neurological disorders.20,21 Broad implications revealed the critical role of RNF proteins in the control or pathogenesis of viral infection, which remains the most formidable challenge to humankind, especially the pandemic coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This evidence concerns the gene TRIM31 and cancer.