PRKN and Parkinson disease: A cell-based high-throughput screening identified that both T0466 and T0467 activate Parkin mitochondrial translocation in a PINK1-dependent manner to suppress mitochondrial aggregation in dopaminergic neurons differentiated from iPS cells.168 However, additional investigation needs to determine these compounds’ molecular targets and address their potential effects in Parkin-associated PD mammalian models.