The PFI score was calculated for 71 variants in genes associated with FH with a median PFI of 0.63 (Q1–Q3 0.25–0.77), with the highest PFI observed in LDLR variants (n = 53, median PFI 0.76, Q1–Q3 0.57–0.80). The gene discussed is LDLR; the disease is familial hyperaldosteronism.