Among them, previous evidence have highlighted the crucial role of Wnt signaling pathways underlying the pathogenesis of mood disorders, specifically for BD (Miola et al., 2022a; Sani et al., 2012), with one of its key enzymes, glycogen synthase kinase-3 beta, which regulates synaptic plasticity, cell survival, and circadian rhythms, involved in the pathophysiology and treatment of BD (Dandekar et al., 2018; Muneer, 2017). This evidence concerns the gene GSK3B and Behcet disease.