Previously, our group correlated the expression of GR and MR in several brain areas (data from the Allen Brain Atlas)69 to the changes in brain volume observed in the extreme hypercortisolism caused by Cushing disease.23 We then concluded that, although a high expression of these receptors was seen in the key brain areas such as the hippocampus, anterior cingulate cortex, and amygdala, there was no clear correlation between receptor expression profiles and brain areas affected by hypercortisolism. This evidence concerns the gene NR3C1 and adrenal gland hyperfunction.