EWSR1 and sarcoma: The hallmark of CCSST is characterized by a balanced t(12;22) (q13;q12) chromosomal translocation, which results in a gene fusion between the Ewing’s sarcoma gene EWSR1 and activating transcription factor 1 (ATF1) to give an oncogene EWSR1-ATF1 (10, 11, 12).