Hypoxia stabilizes HIF1A, which is involved in the growth and metastasis of HCC by activating the transcription of genes, such as vascular endothelial growth factor, that are crucial to cancer metastasis and recurrence.[5, 6] Previous studies have shown that TACE can promote local recurrence and lung metastasis of HCC.[7, 8] To develop an effective approach for predicting the survival benefits from TACE, it is essential to understand the mechanisms of post‐TACE progression. This evidence concerns the gene HIF1A and hepatocellular carcinoma.