Upregulation of S100A8/A9 mRNA in mice brain after induction of focal cerebral ischemia suggested that S100A8/A9 contributes to the progression of ischemic injury.[30] S100A9 was also found to cause cardiomyocyte death in early‐stage myocardial ischemia–reperfusion injury.[31] In this study, ischemia of HCC induced by TACE led to an increase in S100A9 levels in both HCC tissues and serum, which induced post‐TACE HCC progression. Here, S100A9 is linked to hepatocellular carcinoma.