Previous studies have reported that immune cells express and secrete S100A9 and that exogenous S100A9 might promote the proliferation and invasion of HCC cells.[32, 33, 34] Here, we verified that S100A9 was predominantly expressed in EPCAM‐positive cells in HCC tissues, thus playing a role in promoting the recurrence of HCC. The gene discussed is S100A9; the disease is hepatocellular carcinoma.