S100A8 and hepatocellular carcinoma: Upregulation of S100A8/A9 mRNA in mice brain after induction of focal cerebral ischemia suggested that S100A8/A9 contributes to the progression of ischemic injury.[30] S100A9 was also found to cause cardiomyocyte death in early‐stage myocardial ischemia–reperfusion injury.[31] In this study, ischemia of HCC induced by TACE led to an increase in S100A9 levels in both HCC tissues and serum, which induced post‐TACE HCC progression.