SESN2 and pulmonary emphysema: Patients with significant emphysema, as defined by the presence of emphysematous lesions in ≥15% of the pulmonary parenchyma had higher levels of Sesn2 (ng/ml) compared to those with emphysematous lesions in <15% of the pulmonary parenchyma [6.7 (2.7,10.3) vs 1.09 (0.9,1.9), p<0.001, Fig 1].