Using a pulmonary emphysema model induced by inactivating mutation of the small splice variant of the Ltbp4 gene (Ltbp4S–/–), Frank et al. demonstrated that the Sesn2 null alleles (Ltbp4S–/–Sesn2–/–) significantly reduced the pulmonary emphysema of Ltbp4S–/–mice, as Ltbp4S–/–Sesn2–/–mice presented less parenchymal lesions and lung compliance. This evidence concerns the gene LTBP4 and pulmonary emphysema.