TCF7L2, which is ranked first and second in MPS and APS, respectively, is driven by functionally coherent terms, such as abnormal mesoderm morphology (MP:0014141), abnormal somite development (MP:0001688), and abnormal primitive streak morphology (MP:0002231) (S5a Table) in MPS cells, while being driven by less specific terms, such as abnormal germ layer morphology (MP:0014138) in APS cells (S5b Table). This evidence concerns the gene TCF7L2 and autoimmune polyendocrinopathy.