To identify genes or pathways that predict VRK1 dependency, we correlated gene expression data from the Cancer Cell Line Encyclopedia (CCLE) with VRK1 dependency and found that it was most strongly correlated with the loss of expression of its paralog VRK2 (Pearson correlation = 0.37, q < 10–25) (Figure 2A). This evidence concerns the gene VRK2 and cancer.