DM1 samples displayed lower expression levels of CDK2 and HMG2A, involved in the cell cycle; AURKB, CDC45, and CENPA, in cell division; and BRCA1, RAD50, and RAD51, in DDR when compared with a group of healthy individuals of similar age (Figure 3A). The gene discussed is HMGB3; the disease is myotonic dystrophy type 1.