We found a completely different pattern of the secretory phenotype between control and DM1 fibroblasts, with elevated expression of multiple proinflammatory cytokines (IL-6, IL-1α, TNF-α, IL-1β, IFN-γ), chemokines (CCL5), and other factors in DM1 cells at early passage (Figure 5H). Here, IL1B is linked to myotonic dystrophy type 1.