BMI1 and myotonic dystrophy type 1: After confirming the increase in BMI1 expression at the protein (Figure 6A) and mRNA levels (Figure 6B), we performed functional studies and found that BMI1 restoration rescued the impaired cell growth and proliferation of DM1 fibroblasts, to a similar extent to control cells (Figure 6, C and D, and Supplemental Figure 5A).