Our results showed that Quercetin, Dasatinib individually, and Navitoclax (a) selectively eliminated senescent cells, (b) decreased the expression of SASP-related factors, and (c) rescued multiple phenotypes, including significant improvements in locomotor activity and longevity in the REC2 Drosophila model of DM1. Here, RAD51B is linked to myotonic dystrophy type 1.